Rabbit Anti-RSPO2/FITC Conjugated antibody

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CRISTIN2; hRspo2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin family, member 2; Roof plate-specific spondin-2.

Cat:

SL18876R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human RSPO2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

26kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 13366) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]

Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Subunit:
Interacts with WNT1. Binds heparin By similarity. Interacts with LGR4, LGR5 and LGR6.

Subcellular Location:
Secreted

Similarity:
Belongs to the R-spondin family.
Contains 1 FU (furin-like) repeat.
Contains 1 TSP type-1 domain.

Database links:

Entrez Gene: 340419 Human

Entrez Gene: 239405 Mouse

Entrez Gene: 500863 Rat

Omim: 610575 Human

SwissProt: Q6UXX9 Human

SwissProt: Q8SFU0 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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