Rabbit Anti-MGAT4C/FITC Conjugated antibody

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3-D-mannoside beta-1; 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; 4-N-acetylglucosaminyltransferase IVc; Alpha-1; GlcNAc-T IVc; GnT-IVc; hGnT-IV-H; MGAT4C; MGT4C_HUMAN; N-acetylglucosaminyltransferase IV homolog; N-acetylgl

Cat:

SL18909R-FITC

Immunogen：

KLH conjugated synthetic peptide derived from human MGAT4C

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

56kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
MGAT4C is a 478 amino acid single-pass type II membrane protein that localizes to the golgi apparatus and belongs to the glycosyltransferase 54 family. Expressed in liver, heart, testis, brain and adrenal gland, GnT-IVH functions as a glycosyltransferase that catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans, thereby playing a crucial role in the production of tri- and tetra-antennary N-linked sugar chains. The gene encoding GnT-IVH maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

Function:
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).

Subcellular Location:
Golgi apparatus membrane.

Tissue Specificity:
Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas.

Similarity:
Belongs to the glycosyltransferase 54 family.

Database links:

Entrez Gene: 25834 Human

SwissProt: Q9UBM8 Human

Unigene: 589093 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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