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Rabbit Anti-MICAL2/FITC Conjugated antibody
background:
MICAL2 is a 1,124 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Using FAD as a cofactor, MICAL2 interacts with Rab 1B, plexin-A4 and Vimentin and, via these interactions, may play a role in cytoskeletal regulation, specifically at intermediate filaments. MICAL2, which exists as two alternatively spliced isoforms, is expressed at high levels in heart and brain and at lower levels in ovary, skeletal muscle, liver, testis and kidney tissue.
Function:
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Subunit:
Interacts with VIM and PLXNA4 By similarity. Interacts with RAB1B.
Subcellular Location:
Cytoplasm; Nucleus; cytoskeleton.
Similarity:
Belongs to the Mical family.
Contains 1 CH (calponin-homology) domain.
Contains 1 LIM zinc-binding domain.
Database links:
Entrez Gene: 534041 Cow
Entrez Gene: 476858 Dog
Entrez Gene: 9645 Human
Entrez Gene: 64878 Mouse
Entrez Gene: 365352 Rat
Omim: 608881 Human
SwissProt: F1MF74 Cow
SwissProt: O94851 Human
SwissProt: Q8BML1 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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