background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Function:
Activates the JUN N-terminal pathway.
Tissue Specificity:
Expressed in brain and skeletal muscle.
Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 4294 Human
Entrez Gene: 269881 Mouse
Entrez Gene: 308463 Rat
Entrez Gene: 398612 Xenopus laevis
Omim: 600137 Human
SwissProt: Q02779 Human
SwissProt: Q66L42 Mouse
SwissProt: Q7T2V3 Xenopus laevis
Unigene: 466743 Human
Unigene: 389883 Mouse
Unigene: 26500 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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