Rabbit Anti-Naked1/FITC Conjugated antibody

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Dvl-binding protein; Naked cuticle 1; naked cuticle 1 homolog; Naked cuticle homolog 1 (Drosophila); Naked-1; NKD; Nkd1; Protein naked cuticle homolog 1.

Cat:

SL19005R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Naked1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

52kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 13366)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

Subunit:
Interacts with DVL1, DVL2, DVL3 and PPP2R3A.

Subcellular Location:
Cell membrane By similarity. Cytoplasm

Tissue Specificity:
Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.

Similarity:
Belongs to the NKD family. Contains 1 EF-hand domain.

Database links:

Entrez Gene: 85407 Human

Entrez Gene: 93960 Mouse

Entrez Gene: 364952 Rat

Omim: 607851 Human

SwissProt: Q969G9 Human

SwissProt: Q99MH6 Mouse

Unigene: 187578 Human

Unigene: 30219 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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