Rabbit Anti-NALP5/FITC Conjugated antibody

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CLR19.8; MATER; Mater protein homolog; Maternal antigen that embryos require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; NALP5_HUMAN; NLR family, pyrin domain containing 5; NLRP5; Nucleotide-

Cat:

SL19006R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human NALP5

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

134kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a SLCterminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]

Function:
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions

Subunit:
Component of the SCMC which also includes at least OOEP and TLE6

Subcellular Location:
Mitochondrion. Nucleus > nucleolus. Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.

Tissue Specificity:
Oocyte-specific.

Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 13 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.

Database links:

Entrez Gene: 126206 Human

Entrez Gene: 23968 Mouse

Entrez Gene: 308325 Rat

Omim: 609658 Human

SwissProt: P59047 Human

SwissProt: Q9R1M5 Mouse

Unigene: 356872 Human

Unigene: 333653 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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