Rabbit Anti-MYO3A/FITC Conjugated antibody

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deafness, autosomal recessive 30; DFNB30; Myo3a; MYO3A_HUMAN; Myosin IIIA; Myosin-IIIa.

Cat:

SL19171R-FITC

Species Reactivity：

(predicted: Human,Mouse,)

Immunogen：

KLH conjugated synthetic peptide derived from human MYO3A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

186kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable SLCterminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]

Function:
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing.

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas.

DISEASE:
Deafness, autosomal recessive, 30

Similarity:
In the N-terminal section; belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
Contains 3 IQ domains.
Contains 1 myosin head-like domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 53904 Human

Omim: 601368 Human

SwissProt: Q8NEV4 Human

Unigene: 662630 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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