background:
ABI3 is thought to inhibit tumor metastasis. In vitro, ABI3 reduces cell motility.
Function:
May inhibit tumor metastasis. In vitro, reduces cell motility.
Subunit:
May interact with PAK1 and PAK2. Probably interacts with TARSH.
Subcellular Location:
Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells.
Tissue Specificity:
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
Similarity:
Belongs to the ABI family.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 538604 Cow
Entrez Gene: 478544 Dog
Entrez Gene: 100723639 Guinea pig
Entrez Gene: 25890 Human
Entrez Gene: 64712 Mouse
Entrez Gene: 100154641 Pig
Entrez Gene: 363767 Rat
Entrez Gene: 100149890 Zebrafish
Omim: 606279 Human
SwissProt: Q7Z7G0 Human
Unigene: 477015 Human
Unigene: 209236 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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