background:
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Subcellular Location:
Cytoplasm and Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells
Tissue Specificity:
Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Database links:
Entrez Gene: 2172 Human
Entrez Gene: 16204 Mouse
Entrez Gene: 2588 Rat
Omim: 600422 Human
SwissProt: P51161 Human
SwissProt: P51162 Mouse
SwissProt: P80020 Rat
Unigene: 519719 Human
Unigene: 142716 Mouse
Unigene: 10008 Rat
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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