background:
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Function:
Possible role in S-phase checkpoint mechanism.
Subcellular Location:
Nucleus. Nucleus > nucleolus. Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.
Tissue Specificity:
Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 79858 Human
Entrez Gene: 208583 Mouse
Omim: 609779 Human
SwissProt: Q8NG66 Human
SwissProt: Q8C0Q4 Mouse
Unigene: 657336 Human
Unigene: 347509 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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