Rabbit Anti-Nesprin 3/FITC Conjugated antibody

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C14orf49; Chromosome 14 open reading frame 49; FLJ25605; MGC75267; Nesp3; Nesprin3; Nesprin-3; NET53; Nuclear Envelope Spectrin Repeat Protein 3; Spectrin Repeat Containing, Nuclear Envelope Family Member 3; SYNE3; SYNE3_HUMAN.

Cat:

SL19209R-FITC

Species Reactivity：

Human,Mouse,Rat,

Immunogen：

KLH conjugated synthetic peptide derived from human Nesprin 3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

112kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Function:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.

Subcellular Location:
Nucleus outer membrane. Located at the rough reticulum endoplasmic (RER) in some cells.

Similarity:
Belongs to the nesprin family.
Contains 1 KASH domain.
Contains 2 spectrin repeats.

Database links:

Entrez Gene: 490843 Dog

Entrez Gene: 100053652 Horse

Entrez Gene: 161176 Human

Entrez Gene: 212073 Mouse

Entrez Gene: 100525411 Pig

Entrez Gene: 299356 Rat

Omim: 610861 Human

SwissProt: Q6ZMZ3 Human

SwissProt: Q4FZC9 Mouse

Unigene: 354645 Human

Unigene: 212688 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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