Rabbit Anti-SLC32A 1/FITC Conjugated antibody

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VGAT; bA122O1.1; GABA and glycine transporter; hVIAAT; SLC32A 1; solute carrier family 32 (GABA vesicular transporter) member 1; Solute carrier family 32 member 1; Vesicular GABA Amino Acid Transporter; Vesicular GABA transporter; Vesicular inhibitory ami

Cat:

SL10958R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SLC32A 1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

57kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Synaptic transmission involves the controlled exocytosis of vesicles containing specific neurotransmitters. Usually, neurotransmitters are synthesized in the cytoplasm of the cell and must be transported into synaptic vesicles for release. The vesicular GABA transporter (VGAT) is responsible for loading gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, from neuronal cytoplasm into synaptic vesicles and is expressed only in the nerve endings of inhibitory neurons that contain GABA and/or glycine. During neocortical development, VGAT expression barely precedes the maturation of inhibitory synaptogenesis, suggesting that it may contribute to the development of neocortical GABAergic circuitry. VGAT may also play a role in epileptogenesis and the recovery mechanisms that occur after a spontaneous seizure

Function:
Involved in the uptake of GABA and glycine into the synaptic vesicles.

Subcellular Location:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Tissue Specificity:
Retina. Expressed throughout the horizontal cells or more specifically at the terminals.

Similarity:
Belongs to the amino acid/polyamine transporter 2 family.

Database links:

Entrez Gene: 140679 Human

Entrez Gene: 22348 Mouse

Entrez Gene: 83612 Rat

SwissProt: Q9H598 Human

SwissProt: O35633 Mouse

SwissProt: O35458 Rat

Unigene: 179080 Human

Unigene: 143404 Mouse

Unigene: 413854 Mouse

Unigene: 10846 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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