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Rabbit Anti-phospho-NMDAR2B (Ser1303)/FITC Conjugated antibody
background:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
Subcellular Location:
Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
Tissue Specificity:
Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
Database links:
Entrez Gene: 2904 Human
Entrez Gene: 14812 Mouse
Entrez Gene: 24410 Rat
Omim: 138252 Human
SwissProt: Q13224 Human
SwissProt: Q01097 Mouse
SwissProt: Q00960 Rat
Unigene: 654430 Human
Unigene: 436649 Mouse
Unigene: 9711 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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