Rabbit Anti-SAE2 / UBA2/FITC Conjugated antibody

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Anthracycline associated resistance ARX; Anthracycline-associated resistance ARX; ARX; FLJ13058; HRIHFB2115; SAE 2; SAE2; SAE2_HUMAN; SUMO 1 activating enzyme subunit 2; SUMO activating enzyme subunit 2; SUMO-activating enzyme subunit 2; UBA2;

Cat:

SL19366R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human SAE2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

71kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Function:
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the ubiquitin-activating E1 family.

Database links:

Entrez Gene: 10054 Human

Entrez Gene: 50995 Mouse

Entrez Gene: 308508 Rat

Entrez Gene: 406672 Zebrafish

Omim: 613295 Human

SwissProt: Q9UBT2 Human

SwissProt: Q9Z1F9 Mouse

SwissProt: Q7SXG4 Zebrafish

Unigene: 63316 Human

Unigene: 27560 Mouse

Unigene: 198150 Rat

Unigene: 78013 Zebrafish

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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