Rabbit Anti-SAE1/FITC Conjugated antibody

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Activator of SUMO1; AOS 1; AOS1; FLJ3091; HSPC 140; HSPC140; SAE 1; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS 1; Sentrin/SUMO activating protein AOS1; SUA 1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme s

Cat:

SL19364R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human SAE1,Isoform 2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

29kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Subunit:
Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expression level increases during S phase and drops in G2 phase (at protein level).

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the ubiquitin-activating E1 family.

Database links:

Entrez Gene: 10055 Human

Entrez Gene: 56459 Mouse

Entrez Gene: 308384 Rat

Omim: 613294 Human

SwissProt: Q9UBE0 Human

SwissProt: Q9R1T2 Mouse

SwissProt: Q6AXQ0 Rat

Unigene: 515500 Human

Unigene: 258530 Mouse

Unigene: 9014 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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