background:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Function:
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist)
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 59340 Human
Entrez Gene: 225192 Mouse
Entrez Gene: 170704 Rat
Omim: 606792 Human
SwissProt: Q9H3N8 Human
SwissProt: Q91ZY2 Mouse
SwissProt: Q91ZY1 Rat
Unigene: 287388 Human
Unigene: 207073 Mouse
Unigene: 162272 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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