Rabbit Anti-PRP18 homolog/FITC Conjugated antibody

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FLJ10210; hPRP18; Pre mRNA splicing factor 18; Pre-mRNA-splicing factor 18; PRP18; PRP18 homolog; PRP18 pre mRNA processing factor 18 homolog (PRPF18); PRP18 pre mRNA processing factor 18 homolog (S. cerevisiae); PRP18_HUMAN; prpf18.

Cat:

SL19402R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human PRP18 homolog

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

40kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

Function:
Participates in the second step of pre-mRNA splicing.

Subunit:
Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.

Subcellular Location:
Nucleus speckle. Colocalizes with spliceosomal snRNPs.

Similarity:
Belongs to the PRP18 family.

Database links:

Entrez Gene: 507639 Cow

Entrez Gene: 477998 Dog

Entrez Gene: 100727386 Guinea pig

Entrez Gene: 100056558 Horse

Entrez Gene: 8559 Human

Entrez Gene: 67229 Mouse

Entrez Gene: 100513617 Pig

Entrez Gene: 100340516 Rabbit

Entrez Gene: 171552 Rat

Omim: 604993 Human

SwissProt: Q2HJ41 Cow

SwissProt: Q99633 Human

SwissProt: Q8BM39 Mouse

SwissProt: Q9JKB8 Rat

Unigene: 161181 Human

Unigene: 38529 Mouse

Unigene: 203914 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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