Rabbit Anti-GUCA2B/FITC Conjugated antibody

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Prouroguanylin GUCA2B; GCAP II; GCAP-II; Guanylate cyclase activator 2B (uroguanylin); Guanylate cyclase activator 2B; Guanylate cyclase C-activating peptide II; GUC2B_HUMAN; GUCA2B; UGN.

Cat:

SL19400R-FITC

Species Reactivity：

(predicted: Human,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human GUCA2B

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

12kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The family of guanylin regulatory peptides, including guanylin and uroguanylin, are strongly expressed in intestinal mucosa and regulate intestinal fluid secretion during digestion. Guanylins are also involved in acid neutralization and the regulation of membrane-bound guanylate cyclase signaling molecules. Guanylin and uroguanylin are secreted primarily in the stomach, intestine, and colon. Uroguanylin is an endogenous activator of intestinal guanylate cyclase. It is a paracrine and/or autocrine regulator of intestinal water and salt transport. Uroguanylin stimulates intestinal guanylate cyclase through the same receptor binding region as the heat-stable enterotoxins. Uroguanylin is involved in the regulation of intestinal fluid and electrolyte transport.

Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Subcellular Location:
Secreted.

Tissue Specificity:
Stomach and intestine.

Similarity:
Belongs to the guanylin family.

Database links:

Entrez Gene: 2981 Human

Omim: 601271 Human

SwissProt: Q16661 Human

Unigene: 32966 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

与Uroguanylin不同源！姬，2016.12.26；

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