Function:
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Subcellular Location:
Chromosome > centromere > kinetochore. Nucleus. Cytoplasm > cytoskeleton > spindle. Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis.
Similarity:
Belongs to the gfa family.
Database links:
Entrez Gene: 201161 Human
Entrez Gene: 73139 Mouse
Entrez Gene: 501702 Rat
Omim: 608139 Human
SwissProt: Q7Z7K6 Human
SwissProt: Q9CXS4 Mouse
Unigene: 433422 Human
Unigene: 390409 Mouse
Unigene: 483809 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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