background:
PRSS35, although related to the peptidase S1 family, lacks the conserved active Ser residue in position 346 which is replaced by a Thr, suggesting that it has no protease activity. This Ser to Thr substitution may play an important role in determining a unique pattern of substrate specificity for PRSS35. Alternatively, this substitution may yield an inactive protease that binds to specific substrates, thus protecting them from proteolysis. The Mouse Prss35 gene is selectively expressed in the ovary and it's expression prior to ovulation is, in part, regulated by progesterone. PRSS35 may be involved in ovulation and the formation and regression of the corpus luteum.
Subcellular Location:
Secreted
Database links:
Entrez Gene: 167681 Human
Entrez Gene: 244954 Mouse
Entrez Gene: 315866 Rat
SwissProt: Q8N3Z0 Human
SwissProt: Q8C0F9 Mouse
SwissProt: Q5R212 Rat
Unigene: 98381 Human
Unigene: 257629 Mouse
Unigene: 161916 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|