background:
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Subcellular Location:
Nucleus. Remains chromatin-associated throughout the cell cycle.
Tissue Specificity:
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:
Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
Similarity:
Belongs to the HDGF family.
Contains 1 PWWP domain.
Database links:
Entrez Gene: 11168 Human
Entrez Gene: 282011 Cow
Entrez Gene: 101739 Mouse
Entrez Gene: 313323 Rat
Omim: 603620 Human
SwissProt: Q66T72 Cat
SwissProt: O75475 Human
SwissProt: Q99JF8 Mouse
SwissProt: Q812D1 Rat
Unigene: 726445 Human
Unigene: 105331 Mouse
Unigene: 448301 Mouse
Unigene: 93075 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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