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Rabbit Anti-PSMC3IP/FITC Conjugated antibody
background:
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Function:
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HISLV1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in testis and colon.
Post-translational modifications:
PTM: Phosphorylated by PKA, PKC and MAPK.
DISEASE:
Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the HOP2 family.
Database links:
ntrez Gene: 29893 Human
Entrez Gene: 19183 Mouse
Entrez Gene: 140938 Rat
Omim: 608665 Human
SwissProt: Q9P2W1 Human
SwissProt: O35047 Mouse
SwissProt: Q91ZY6 Rat
Unigene: 383019 Human
Unigene: 18344 Mouse
Unigene: 144650 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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