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Rabbit Anti-SEC62/FITC Conjugated antibody
background:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Function:
Required for preprotein translocation.
Subunit:
Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the SEC62 family.
Database links:
Entrez Gene: 7095 Human
Entrez Gene: 69276 Mouse
Entrez Gene: 294912 Rat
Omim: 602173 Human
SwissProt: Q99442 Human
SwissProt: Q8BU14 Mouse
Unigene: 592561 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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