Subunit:
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 8111 Human
Entrez Gene: 281799 Cow
Entrez Gene: 100688992 Dog
Entrez Gene: 101128436 Gorilla
Entrez Gene: 100053071 Horse
Entrez Gene: 238377 Mouse
Entrez Gene: 100153615 Pig
Entrez Gene: 100348269 Rabbit
Omim: 601404 Human
SwissProt: O46685 Cow
SwissProt: Q15743 Human
SwissProt: Q8SFQ3 Mouse
Unigene: 8882 Human
Unigene: 32160 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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