Rabbit Anti-nSMase/FITC Conjugated antibody

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ISC1; Lyso platelet activating factor phospholipase C; Lyso-PAF-PLC; Lyso-platelet-activating factor-phospholipase C; N-SMase; Neutral sphingomyelinase; NSMA_HUMAN; nSMase; NSMASE1; Smpd2; Sphingomyelin phosphodiesterase 2; Sphingomyelin phosph

Cat:

SL19472R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human nSMase

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

Function:
Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.

Subcellular Location:
Membrane.

Similarity:
Belongs to the neutral sphingomyelinase family.

Database links:

Entrez Gene: 6610 Human

Entrez Gene: 20598 Mouse

Omim: 603498 Human

SwissProt: O60906 Human

SwissProt: O70572 Mouse

SwissProt: Q8BW85 Mouse

SwissProt: Q8C6H6 Mouse

Unigene: 55235 Human

Unigene: 953 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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