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Rabbit Anti-NSL1/FITC Conjugated antibody
background:
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
Subunit:
Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5.
Subcellular Location:
Nucleus. Chromosome > centromere > kinetochore. Associated with the kinetochore.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Database links:
Entrez Gene: 25936 Human
SwissProt: Q96IY1 Human
Unigene: 497692 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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