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Rabbit Anti-SerpinB8/FITC Conjugated antibody
background:
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and SLCterminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the serpin family. Ov-serpin subfamily.
Database links:
Entrez Gene: 5271 Human
Entrez Gene: 20725 Mouse
Entrez Gene: 288937 Rat
Omim: 601697 Human
SwissProt: P50452 Human
SwissProt: O01760 Mouse
Unigene: 73677 Human
Unigene: 83909 Mouse
Unigene: 104823 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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