background:
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Function:
Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Subcellular Location:
Cytoplasm. Mitochondrion. Nucleus. Weakly associates with mitochondria, possibly via QTRTD1.
Similarity:
Belongs to the queuine tRNA-ribosyltransferase family.
Database links:
Entrez Gene: 476711 Dog
Entrez Gene: 81890 Human
Entrez Gene: 60507 Mouse
Entrez Gene: 12816 Rat
Entrez Gene: 393985 Zebrafish
Omim: 609615 Human
SwissProt: Q9BXR0 Human
SwissProt: Q9JMA2 Mouse
SwissProt: Q4QR99 Rat
SwissProt: Q7SYK1 Zebrafish
Unigene: 631638 Human
Unigene: 436579 Mouse
Unigene: 53858 Rat
Unigene: 9747 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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