Rabbit Anti-Endophilin II/FITC Conjugated antibody

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SH3 containing Grb 2 like 1 protein; Endophilin II; CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 co

Cat:

SL19747R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Endophilin II

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

41kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Function:
Implicated in endocytosis. May recruit other proteins to membranes with high curvature.

Subcellular Location:
Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons.

Tissue Specificity:
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

DISEASE:
Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.

Similarity:
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 512719 Cow

Entrez Gene: 6455 Human

Entrez Gene: 20405 Mouse

Entrez Gene: 81922 Rat

Omim: 601768 Human

SwissProt: Q2KJA1 Cow

SwissProt: Q99961 Human

SwissProt: Q62419 Mouse

SwissProt: O35964 Rat

Unigene: 97616 Human

Unigene: 1773 Mouse

Unigene: 8762 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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