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Rabbit Anti-RASA4/FITC Conjugated antibody
background:
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
Subcellular Location:
Cytoplasm; cytosol. Cell membrane; peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 1 Ras-GAP domain.
Database links:
Entrez Gene: 10156 Human
Entrez Gene: 54153 Mouse
Entrez Gene: 288589 Rat
Omim: 607943 Human
SwissProt: O43374 Human
SwissProt: Q6PFQ7 Mouse
Unigene: 696339 Human
Unigene: 290655 Mouse
Unigene: 1366 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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