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Home > Product > Antibody > Rabbit Anti-RBM14/FITC Conjugated antibody
CoAA; Coactivator Activator; RBM 14; RBM14; RNA binding motif protein 14; RNA binding protein 14; RRM containing coactivator activator/modulator; SIP; Synaptotagmin interacting protein; SYT interacting protein 1; SYT interacting protein; SYT in
Cat:
SL19763R-FITC
Species Reactivity：
Human,Mouse,(predicted: Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,Guinea Pig,)
Immunogen：
KLH conjugated synthetic peptide derived from human RBM14
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
69kDa
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Product PDFs
Datasheet:


background:
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the SLCterminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.

Subunit:
Isoform 1 interacts with NCOA6, CITED1 and XRCC5/KU86. Isoform 1 interacts with SS18 isoform 1. Isoform 1 interacts with SS18 isoform 2.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.

Similarity:
Contains 2 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 511512 Cow

Entrez Gene: 10432 Human

Entrez Gene: 56275 Mouse

Entrez Gene: 170900 Rat

Omim: 61489 Human

SwissProt: Q5EA36 Cow

SwissProt: Q96PK6 Human

SwissProt: Q8C2Q3 Mouse

Unigene: 533712 Human

Unigene: 8556 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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