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Rabbit Anti-RBBP9/FITC Conjugated antibody
background:
The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008]
Function:
May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues.
Similarity:
Belongs to the RBBP9 family.
Database links:
Entrez Gene: 10741 Human
Entrez Gene: 26450 Mouse
Entrez Gene: 29459 Rat
Omim: 602908 Human
SwissProt: O75884 Human
SwissProt: O88851 Mouse
SwissProt: O88350 Rat
Unigene: 69330 Human
Unigene: 88564 Mouse
Unigene: 162693 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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