Function:
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
Subunit:
Homotrimer. Interacts with matrix protein.
Subcellular Location:
Virion membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Post-translational modifications:
Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface. {ECO:0000269|PubMed:1587845, ECO:0000269|PubMed:9451021}.
Similarity:
Belongs to the lyssavirus glycoprotein family.
Database links:
Entrez Gene: 1489856 Rabies virus
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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