Function:
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.
Subunit:
Interacts with NFKB1, RELA and RELB; in the nucleus.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats.
Database links:
Entrez Gene: 8967 Human
Entrez Gene: 243910 Mouse
Entrez Gene: 308496 Rat
SwissProt: Q8NI38 Human
SwissProt: Q2TB02 Mouse
Unigene: 466531 Human
Unigene: 386878 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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