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Rabbit Anti-RECQ1/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described. [provided by RefSeq, Jul 2008]
Function:
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
Subunit:
Interacts with EXO1 and MLH1.
Subcellular Location:
Nuclear
Tissue Specificity:
High expression in heart, lung, skeletal muscle and kidney, low expression in brain.
Similarity:
Belongs to the helicase family. RecQ subfamily
Contains 1 helicase ATP-binding domain
Contains 1 helicase SLCterminal domain.
Database links:
Entrez Gene: 5965 Human
Entrez Gene: 19691 Mouse
Omim: 600537 Human
SwissProt: P9263 Human
SwissProt: Q9Z129 Mouse
Unigene: 235069 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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