background:
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]
Function:
Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest amounts are found in placenta, lung and heart.
Similarity:
Contains 2 RRM (RNA recognition motif) domains.
Database links:
Entrez Gene: 395176 Chicken
Entrez Gene: 526135 Cow
Entrez Gene: 5937 Human
Entrez Gene: 56878 Mouse
Entrez Gene: 362138 Rat
GenBank: NP_058520.1 Human
Omim: 602310 Human
SwissProt: Q3ZBP3 Cow
SwissProt: P29558 Human
SwissProt: Q91W59 Mouse
SwissProt: Q5PQP1 Rat
Unigene: 470412 Human
Unigene: 708357 Human
Unigene: 259667 Mouse
Unigene: 482338 Mouse
Unigene: 98522 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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