background:
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Subcellular Location:
Basolateral cell membrane. Apical side of the renal tubule.
Tissue Specificity:
Expressed in liver and kidney.
Similarity:
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Database links:
Entrez Gene: 10864 Human
Entrez Gene: 108114 Mouse
Entrez Gene: 733693 Pig
Entrez Gene: 89776 Rat
Omim: 604995 Human
SwissProt: Q9Y694 Human
SwissProt: Q91WU2 Mouse
SwissProt: Q1RPP5 Pig
SwissProt: Q5RLM2 Rat
SwissProt: Q63314 Rat
Unigene: 485438 Human
Unigene: 387538 Mouse
Unigene: 10009 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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