background:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
Tissue Specificity:
B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
Post-translational modifications:
Could be phosphorylated. Might be functionally regulated by protein kinase(s).
Similarity:
Contains 1 RGS domain.
Database links:
Entrez Gene: 100034151 Horse
Entrez Gene: 5996 Human
Entrez Gene: 50778 Mouse
Entrez Gene: 54289 Rat
Omim: 600323 Human
SwissProt: Q6RG78 Horse
SwissProt: Q08116 Human
SwissProt: Q9JL25 Mouse
SwissProt: P97844 Rat
Unigene: 75256 Human
Unigene: 103701 Mouse
Unigene: 14787 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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