Rabbit Anti-REXO1/FITC Conjugated antibody

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EloA BP1; ELOABP1; Elongin A binding protein 1; KIAA1138; REX1, RNA exonuclease 1 homolog (S. cerevisiae); RNA exonuclease 1 homolog; TCEB3BP1; Transcription elongation factor B polypeptide 3 binding protein 1.

Cat:

SL19839R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human REXO1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

131kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
REXO1 or Elongin A-binding protein 1 (EloA-BP1) is an exonuclease domain-containing protein that can bind to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although REXO1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo.

Function:
Seems to have no detectable effect on transcription elongation in vitro.

Subunit:
Interacts with TCEA2 and TCEB3.

Subcellular Location:
Nuclear

Similarity:
Belongs to the REXO1/REXO3 family.
Contains 1 exonuclease domain.

Database links:

Entrez Gene: 57455 Human

Omim: 609614 Human

SwissProt: Q8N1G1 Human

Unigene: 192477 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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