Rabbit Anti-PARP9/FITC Conjugated antibody

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ADP-ribosyltransferase diphtheria toxin-like 9; ARTD9; AW214463; B aggressive lymphoma protein; Bagl; BAL; BAL1; BC003281; DKFZp666B0810; DKFZp686M15238; EC 2.4.2.30; FLJ26637; FLJ35310; FLJ41418; FLJ43593; MGC:7868; MGC156739; MGC7868;

Cat:

SL19890R-FITC

Species Reactivity：

(predicted: Human,Mouse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PARP9

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

97kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Function:
Involved in inducing the expression of IFN-gamma-responsive genes.

Subcellular Location:
Cytoplasm > cytosol. Nucleus. Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L.

Tissue Specificity:
Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.

DISEASE:
Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.

Similarity:
Contains 2 Macro domains.
Contains 1 PARP catalytic domain.

Database links:

Entrez Gene: 83666 Human

Entrez Gene: 80285 Mouse

SwissProt: Q8IXQ6 Human

SwissProt: Q8CAS9 Mouse

Unigene: 518200 Human

Unigene: 49074 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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