Home > Product > Antibody > Rabbit Anti-PC5/PC6/FITC Conjugated antibody
FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; PCSK5; PCSK5_HUMAN; Prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; Proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; Protease PC6; SPC6; Subtilisi
Cat:
SL19904R-FITC
Species Reactivity:
(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep,)
Immunogen:
KLH conjugated synthetic peptide derived from human PC5/PC6
Format:
Lyophilized or Liquid
Storage instructions:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Calculated MW:
194,101kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HISLV1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

Function:
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in T-lymphocytes.

Similarity:
Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.
Contains 1 PLAC domain.

Database links:

Entrez Gene: 5125 Human

Entrez Gene: 18552 Mouse

Entrez Gene: 116548 Rat

Omim: 600488 Human

SwissProt: Q92824 Human

SwissProt: Q04592 Mouse

SwissProt: P41413 Rat

Unigene: 368542 Human

Unigene: 3401 Mouse

Unigene: 104002 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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