Rabbit Anti-PC4/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-PC4/FITC Conjugated antibody

Activated RNA polymerase II transcriptional coactivator p15; Interferon related developmental regulator 1; MGC102747; p14; P15; PC4; PC4 LSB; Positive cofactor 4; RPO2TC1; Sub1; SUB1 homolog; TCP4_HUMAN

Cat:

SL19903R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human PC4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

14kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Subunit:
Interacts with PSIP1/LEDGF.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in a variety of tissues.

Post-translational modifications:
Activity is controlled by protein kinases that target the regulatory region.
Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.

Similarity:
Belongs to the transcriptional coactivator PC4 family.

Database links:

Entrez Gene: 10923 Human

Entrez Gene: 20024 Mouse

Entrez Gene: 192269 Rat

Omim: 600503 Human

SwissProt: P53999 Human

SwissProt: P11031 Mouse

SwissProt: Q63396 Rat

Unigene: 229641 Human

Unigene: 644972 Human

Unigene: 41746 Mouse

Unigene: 8706 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall