Rabbit Anti-TIMM22/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-TIMM22/FITC Conjugated antibody

Mitochondrial import inner membrane translocase subunit Tim22; Putative membrane protein; Testis expressed sequence 4; TEX 4; TEX4; TIM 22; TIM22; TIMM 22; Translocase of inner mitochondrial membrane 22 homolog.

Cat:

SL19931R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TIMM22

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

20kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
TIMM22 is an essential core component of the TIM22 protein insertion complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated, signal-gated hydrophilic high-conductance channel. It forms a twin-pore translocase that uses the membrane potential as an external driving force in 2 voltage-dependent steps.

Function:
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).

Subunit:
Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.

Similarity:
Belongs to the Tim17/Tim22/Tim23 family.

Database links:

Entrez Gene: 29928 Human

Entrez Gene: 56322 Mouse

Entrez Gene: 79463 Rat

Omim: 607251 Human

SwissProt: Q9Y584 Human

SwissProt: Q9CQ85 Mouse

SwissProt: Q9JKW1 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall