background:
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Function:
Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.
Similarity:
Belongs to the serine esterase family.
Database links:
Entrez Gene: 5051 Human
Entrez Gene: 100163 Mouse
Entrez Gene: 313611 Rat
Omim: 602344 Human
SwissProt: Q99487 Human
SwissProt: Q8VDG7 Mouse
SwissProt: P83006 Rat
Unigene: 477083 Human
Unigene: 22116 Mouse
Unigene: 92487 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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