background:
VASN (Vasorin) is a Protein Coding gene. GO annotations related to this gene include transforming growth factor beta binding.
Function:
May act as an inhibitor of TGF-beta signaling.
Subunit:
Interacts with TGFB1, TGFB2 and TGFB3.
Subcellular Location:
Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.
Post-translational modifications:
N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
Similarity:
Contains 1 EGF-like domain.
Contains 1 fibronectin type-III domain.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Database links:
Entrez Gene: 114990 Human
Entrez Gene: 246154 Mouse
Entrez Gene: 679921 Rat
Omim: 608843 Human
SwissProt: Q6EMK4 Human
SwissProt: Q9CZT5 Mouse
Unigene: 372579 Human
Unigene: 482140 Mouse
Unigene: 198255 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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