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Rabbit Anti-phospho-PDGFRA (Tyr720)/FITC Conjugated antibody
background:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Function:
Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
DISEASE:
Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 5156 Human
Entrez Gene: 18595 Mouse
Entrez Gene: 25267 Rat
Omim: 173490 Human
SwissProt: P16234 Human
SwissProt: P26618 Mouse
SwissProt: P20786 Rat
Unigene: 74615 Human
Unigene: 221403 Mouse
Unigene: 55127 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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