background:
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Function:
Scaffold protein which probably links Toll-like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK kinases and TRAF6. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Probably involved in innate immune response.
Tissue Specificity:
Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung.
Similarity:
Belongs to the pellino family.
Database links:
Entrez Gene: 246330 Human
Entrez Gene: 48518 Mouse
Entrez Gene: 309157 Rat
Omim: 609827 Human
SwissProt: Q8N2H9 Human
SwissProt: Q8BXR6 Mouse
Unigene: 656875 Human
Unigene: 277580 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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