background:
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
Function:
Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization
Subcellular Location:
Lysosome
Tissue Specificity:
Ubiquitously expressed. Highly expressed in tumor cells.
Similarity:
Belongs to the phosphatidylethanolamine-binding protein family.
Database links:
Entrez Gene: 157310 Human
Omim: 612473 Human
SwissProt: Q96S96 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|