Rabbit Anti-SMNDC1/FITC Conjugated antibody

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30 kDa splicing factor SMNrp; MGC106917; MGC112663; SMN related protein; SMN-related protein; smndc1; SMNR; SPF30; SPF30_HUMAN; Splicing factor 30, survival of motor neuron-related; Survival motor neuron domain containing 1; Survival motor neur

Cat:

SL12128R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SMNDC1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

26kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]

Function:
Necessary for spliceosome assembly. Overexpression causes apoptosis.

Subcellular Location:
Nucleus speckle. Nucleus > Cajal body. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.

Tissue Specificity:
Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.

Similarity:
Belongs to the SMN family.
Contains 1 Tudor domain.

Database links:

Entrez Gene: 520500 Cow

Entrez Gene: 10285 Human

Entrez Gene: 76479 Mouse

Entrez Gene: 287768 Rat

Entrez Gene: 572679 Zebrafish

Omim: 603519 Human

SwissProt: Q3T045 Cow

SwissProt: O75940 Human

SwissProt: Q8BGT7 Mouse

SwissProt: Q4QQU6 Rat

SwissProt: Q7ZV80 Zebrafish

Unigene: 66493 Human

Unigene: 313687 Mouse

Unigene: 103854 Rat

Unigene: 75917 Zebrafish

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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