Rabbit Anti-Periplakin/FITC Conjugated antibody

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190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl.

Cat:

SL0350R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Periplak

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

205kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its SLCterminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

Subcellular Location:
Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.

Tissue Specificity:
Expressed in stratified squamous epithelia and in some other epithelia.

Similarity:
Belongs to the plakin or cytolinker family.
Contains 2 plectin repeats.
Contains 4 spectrin repeats.

Database links:

Entrez Gene: 5493 Human

Entrez Gene: 19041 Mouse

Entrez Gene: 302934 Rat

Omim: 602871 Human

SwissProt: O60437 Human

SwissProt: Q9R269 Mouse

Unigene: 192233 Human

Unigene: 266875 Mouse

Unigene: 25259 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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